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Author Yagdi, Tahir ♦ Sharples, Linda ♦ Tsui, Steven ♦ Large, Stephen ♦ Parameshwar, Jayan
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Diseases ♦ Surgery & related medical specialties ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Neoplasms ♦ Diseases ♦ Surgical Procedures, Operative ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons ♦ Geographic Locations ♦ Geographic Locations
Subject Keyword Discipline Cardiology ♦ Discipline Surgery ♦ Heart Transplantation ♦ Adverse Effects ♦ Kidney Neoplasms ♦ Etiology ♦ Lymphoma ♦ Skin Neoplasms ♦ Adolescent ♦ Adult ♦ Aged ♦ Analysis Of Variance ♦ Female ♦ Humans ♦ Incidence ♦ Kaplan-meier Estimate ♦ Epidemiology ♦ Mortality ♦ Male ♦ Middle Aged ♦ Proportional Hazards Models ♦ Retrospective Studies ♦ Risk Factors ♦ Time Factors ♦ Turkey ♦ Great Britain ♦ Young Adult ♦ Journal Article
Abstract BACKGROUND: Malignancy is an important complication after heart transplantation. The incidence, spectrum, risk factors, and clinical impact of posttransplant malignancy were investigated in a cohort of patients with long-term follow-up at a single center. METHODS: Data for 835 patients who underwent heart transplantation between 1979 and 2002 and survived beyond one month were retrospectively evaluated for posttransplant skin cancer, solid organ tumors, and lymphoma. RESULTS: One hundred thirty-nine malignancies developed in 126 patients (15.1%). Skin cancer, solid organ tumors, and lymphoma represented 49%, 27%, and 24% of the malignancies, respectively. Mean patient age at transplantation for patients developing skin cancer, solid organ tumor, and lymphoma were 50 years, 51 years, and 46 years, respectively (p = 0.024). Risk factors for skin cancer were: age greater than 40 at transplantation, number of treated rejection episodes in the first year after transplantation, and smoking history. Variables associated with solid organ malignancy development were age and smoking history. There was no variable related to the development of posttransplant lymphoma. Median survival after diagnosis of skin cancer, solid organ tumor, and lymphoma were 5.0 years, 0.3 years, and 0.7 years, respectively (p < 0.001). CONCLUSIONS: Posttransplant malignancies have different risk factors and variable clinical impact. Older age at transplantation, smoking history, and more episodes of treated rejection were related to increased incidence of nonlymphoid malignancy incidence after heart transplantation, whereas no variable was associated with lymphoid malignancy. Skin cancers have a benign course, while solid organ malignancies and lymphomas carry an unfavorable prognosis.
Spatial Coverage Turkey
Description Country affiliation: United kingdom
Author Affiliation: Yagdi T ( Transplant Unit, Papworth Hospital, Cambridge, UK. tahir.yagdi@ege.edu.tr)
ISSN 08860440
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2009-09-01
Publisher Place United States
e-ISSN 15408191
Journal Journal of Cardiac Surgery
Volume Number 24
Issue Number 5


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Source: WHO-Global Index Medicus