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Author Vistoropsky, Yulia ♦ Heiblum, Rachel ♦ Smorodinsky, Nechama-Ina ♦ Barnea, Anat
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Keyword Discipline Neurology
Abstract Neurogenesis and neuronal recruitment occur in adult brains of many vertebrates, and the hypothesis is that these phenomena contribute to the brain plasticity that enables organisms to adjust to environmental changes. In mammals, vasoactive intestinal polypeptide (VIP) is known to have many neuroprotective properties, but in the avian brain, although widely distributed, its role in neuronal recruitment is not yet understood. In the present study we actively immunized adult zebra finches against VIP conjugated to KLH and compared neuronal recruitment in their brains, with brains of control birds, which were immunized against KLH. We looked at two forebrain regions: the nidopallium caudale (NC), which plays a role in vocal communication, and the hippocampus (HC), which is involved in the processing of spatial information. Our data demonstrate that active immunization against VIP reduces neuronal recruitment, inhibits reproduction, and induces molting, with no change in plasma prolactin levels. Thus, our observations suggest that VIP has a direct positive role in neuronal recruitment and reproduction in birds. J. Comp. Neurol. 524:2516-2528, 2016. © 2016 Wiley Periodicals, Inc.
Description Country affiliation: Israel
Author Affiliation: Vistoropsky Y ( Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, 43107, Israel.); Heiblum R ( Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, 43107, Israel.); Smorodinsky NI ( Department of Cell Research & Immunology, The George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, 61391, Israel.); Barnea A ( Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, 43107, Israel.)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-08-15
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 524
Issue Number 12


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Source: WHO-Global Index Medicus