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Author Garbuzova-Davis, Svitlana ♦ Haller, Edward ♦ Williams, Stephanie N. ♦ Haim, Eithan D. ♦ Tajiri, Naoki ♦ Hernandez-Ontiveros, Diana G. ♦ Frisina-Deyo, Aric ♦ Boffeli, Sean M. ♦ Sanberg, Paul R. ♦ Borlongan, Cesario V.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Incidence & prevention of disease ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cardiovascular System ♦ Nervous System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Nervous System Diseases ♦ Animal Diseases ♦ Diseases ♦ Macromolecular Substances ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Psychological Phenomena and Processes ♦ Psychiatry and Psychology
Subject Keyword Discipline Neurology ♦ Blood-brain Barrier ♦ Physiopathology ♦ Corpus Striatum ♦ Pathology ♦ Infarction, Middle Cerebral Artery ♦ Motor Cortex ♦ Analysis Of Variance ♦ Animals ♦ Apoptosis Regulatory Proteins ♦ Metabolism ♦ Astrocytes ♦ Ultrastructure ♦ Disease Models, Animal ♦ Functional Laterality ♦ Glial Fibrillary Acidic Protein ♦ Male ♦ Microscopy, Electron, Transmission ♦ Microvessels ♦ Rats ♦ Rats, Sprague-dawley ♦ Journal Article ♦ Research Support, N.i.h., Extramural ♦ Research Support, Non-u.s. Gov't
Abstract Stroke is a life-threatening disease leading to long-term disability in stroke survivors. Cerebral functional insufficiency in chronic stroke might be due to pathological changes in brain areas remote from the initial ischemic lesion, i.e., diaschisis. Previously, we showed that the damaged blood-brain barrier (BBB) was involved in subacute diaschisis. The present study investigated BBB competence in chronic diaschisis by using a transient middle cerebral artery occlusion (tMCAO) rat model. Our results demonstrated significant BBB damage mostly in the ipsilateral striatum and motor cortex in rats at 30 days after tMCAO. The BBB alterations were also determined in the contralateral hemisphere via ultrastructural and immunohistochemical analyses. Major BBB pathological changes in contralateral remote striatum and motor cortex areas included 1) vacuolated endothelial cells containing large autophagosomes, 2) degenerated pericytes displaying mitochondria with cristae disruption, 3) degenerated astrocytes and perivascular edema, 4) Evans blue extravasation, and 5) appearance of parenchymal astrogliosis. Discrete analyses of striatal and motor cortex areas revealed significantly higher autophagosome accumulation in capillaries of ventral striatum and astrogliosis in dorsal striatum in both cerebral hemispheres. These widespread microvascular alterations in ipsilateral and contralateral brain hemispheres suggest persistent and/or continued BBB damage in chronic ischemia. The pathological changes in remote brain areas likely indicate chronic ischemic diaschisis, which should be considered in the development of treatment strategies for stroke.
Description Author Affiliation: Garbuzova-Davis S ( Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-09-01
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 522
Issue Number 13

Source: WHO-Global Index Medicus