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Author Gesin, Gail ♦ Kane-Gill, Sandra L. ♦ Dasta, Joseph F. ♦ Birrer, Kara L. ♦ Kolnik, Lyle J. ♦ Cheatham, Michael L.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Social problems & services; associations ♦ Social welfare problems & services ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Pathological Conditions, Signs and Symptoms ♦ Wounds and Injuries ♦ Diseases ♦ Heterocyclic Compounds ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Therapeutics ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physiological Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons ♦ Health Care Facilities, Manpower, and Services ♦ Health Care
Subject Keyword Discipline Critical Care ♦ Critical Illness ♦ Diazepam ♦ Therapeutic Use ♦ Hypnotics And Sedatives ♦ Wounds And Injuries ♦ Drug Therapy ♦ Apache ♦ Adult ♦ Administration & Dosage ♦ Adverse Effects ♦ Drug Interactions ♦ Drug Therapy, Combination ♦ Female ♦ Humans ♦ Intensive Care Units ♦ Length Of Stay ♦ Lorazepam ♦ Male ♦ Midazolam ♦ Prospective Studies ♦ Respiration, Artificial ♦ Therapy ♦ Journal Article ♦ Research Support, U.s. Gov't, Non-p.h.s.
Abstract PURPOSE: Limited information addressing the safety and efficacy of diazepam in the intensive care unit, particularly in trauma patients, is available. The purpose of this study is to evaluate the safety and efficacy of diazepam when used in routine clinical practice as a component of a goal-directed sedation regimen in critically ill trauma patients. MATERIAL AND METHODS: This is a prospective observational evaluation of adult trauma patients admitted to an intensive care unit with orders for as-needed midazolam or lorazepam followed by scheduled diazepam. Medication administration and Sedation-Agitation Scale scores were recorded. RESULTS: Twenty-four patients were evaluated. The most common diazepam dosage was 10 mg every 6 hours, and individual doses ranged from 5 to 30 mg. Sedation-Agitation Scale scores were recorded a median of 20 times per day (interquartile range, 15-24), and the majority (68%) were in the target range. No diazepam-related adverse events were observed. CONCLUSIONS: Based on this limited sample, the use of diazepam as a component of goal-directed therapy appears safe and effective in providing adequate sedation in critically ill trauma patients using an average dosage of 40 mg/d.
Description Country affiliation: United States
Author Affiliation: Gesin G ( Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-04-01
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 26
Issue Number 2

Source: WHO-Global Index Medicus