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Author Suarez-de-la-Rica, Alejandro ♦ Anillo, Víctor ♦ Montero, Ana ♦ Hernandez-Gancedo, Carmen ♦ Lopez-Tofiño, Araceli ♦ Gilsanz, Fernando ♦ Maseda, Emilio
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Keyword Discipline Critical Care
Abstract PURPOSE: The aim was to determine the factors related to acute kidney injury (AKI) in surgical septic patients with complicated intra-abdominal infection (CIAI) and mortality associated to AKI. METHODS: An observational study was performed in patients with CIAI requiring surgery and ICU admission (June 2011-June 2013). Factors at admission associated with developing of AKI and renal replacement therapy (RRT) and association between mortality and AKI and RRT were studied. RESULTS: A total of 114 patients were included. Developing of AKI was independently associated with the sequential organ failure assessment (SOFA) score (odds ratio [OR], 1.570; 95% confidence interval [CI], 1.286-2.016) and creatinine at admission (OR for 0.1 units, 1.560; 95% CI, 1.296-1.990). Renal replacement therapy was independently associated with arterial hypertension (OR, 4.896; 95% CI, 1.501-15.971) and SOFA (OR, 1.713; 95% CI, 1.377-2.132). In another model with more predictive capacity, the number of previous medications that may alter renal function (OR, 3.732; 95% CI, 1.923-8.383) and SOFA (OR, 1.860; 95% CI, 1.469-2.541) were related to RRT. Both AKI and RRT were related to intensive care unit (P=.014 and P<.001, respectively) and 28-day mortality (P=.045 and P<.001, respectively). CONCLUSIONS: Acute kidney injury in patients with CIAI is clearly associated with SOFA and creatinine at admission. Severe AKI with RRT need is highly associated with both previous arterial hypertension and the number of previous medications potentially affecting renal function.
Description Author Affiliation: Suarez-de-la-Rica A ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain. Electronic address: alejandro.suarez.delarica@gmail.com.); Anillo V ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.); Montero A ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.); Hernandez-Gancedo C ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.); Lopez-Tofiño A ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.); Gilsanz F ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.); Maseda E ( Department of Anesthesiology and Surgical Critical Care, Hospital Universitario La Paz, Madrid 28046, Spain.)
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-11-09
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 38


Source: WHO-Global Index Medicus