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Author Abid, Kalthoum ♦ El Mezni, Faouzi ♦ Kamoun, Mohamed Ridha ♦ Fazaa, Becima ♦ Zermani, Rachida ♦ Hadouchi, Chokri ♦ Hamzaoui, Kamel
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cells ♦ Integumentary System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Neoplasms ♦ Diseases ♦ Amino Acids, Peptides, and Proteins ♦ Biological Factors ♦ Chemicals and Drugs ♦ Diagnosis ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Cell Physiological Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons
Subject Keyword Discipline Pathology ♦ Discipline Dermatology ♦ Carcinoma, Basal Cell ♦ Metabolism ♦ Keratinocytes ♦ Skin Neoplasms ♦ Skin ♦ Xeroderma Pigmentosum ♦ Adolescent ♦ Adult ♦ Aged ♦ Aged, 80 And Over ♦ Antigens, Cd ♦ Apoptosis ♦ Immunology ♦ Basal Cell Nevus Syndrome ♦ Cell Survival ♦ Genetics ♦ Child ♦ Female ♦ Humans ♦ Immunohistochemistry ♦ Pathology ♦ Male ♦ Middle Aged ♦ Proto-oncogene Proteins C-bcl-2 ♦ Bcl-2-associated X Protein ♦ Journal Article
Abstract A unique feature of the skin immune system is its proximity to cells continuously exposed to sun rays, as it is located in the interface between the body and the environment. In this study, we aimed to determine the impact of DNA damaged keratinocytes on the expression of apoptotic-related molecules, in T-cells of the inflammatory component of the tumor environment. Immunohistochemistry was performed on tissue sections derived from skin biopsies of basal cell carcinomas (BCCs) of xeroderma pigmentosum (XP) patients, non-XP patients and nevoid basal cell carcinoma syndrome (NBCCS) patients, using antibodies against B-cell lymphoma/leukemia-2 (Bcl-2), Bcl-2 associated X protein (Bax), CD95, CD3, CD8 and CD56. Our results showed significantly lower levels of expression of the antiapoptotic Bcl-2 molecule, in XP, in comparison with non-XP and NBCCS T-lymphocytes, leading to the highest Bax/Bcl-2 ratio for XP T-cells. For the CD95 receptor expression levels, there were significant differences among T-cells of the three patient subgroups as well. The higher propensity of XP T-cells to undergo apoptosis may have evolved in individual XP patients, apparently during the course of their disease, to maintain a special skin as an immune privilege site for tumors' development.
Description Country affiliation: Tunisia
Author Affiliation: Abid K ( Immuno-Histology Laboratory, Medicine University of Tunis, Tunisia. abid_kalthoum@yahoo.fr)
ISSN 03036987
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-04-01
Publisher Place United States
e-ISSN 16000560
Journal Journal of Cutaneous Pathology
Volume Number 37
Issue Number 4


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Source: WHO-Global Index Medicus