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Author Riga, Maria ♦ Danielidis, Vasilios ♦ Pneumatikos, Ioannis
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Social problems & services; associations ♦ Social welfare problems & services ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Bacterial Infections and Mycoses ♦ Respiratory Tract Diseases ♦ Diseases ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Therapeutics ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Microbiological Phenomena ♦ Biological Sciences ♦ Health Care Facilities, Manpower, and Services ♦ Health Care
Subject Keyword Discipline Critical Care ♦ Cross Infection ♦ Etiology ♦ Rhinitis ♦ Sinusitis ♦ Anti-bacterial Agents ♦ Administration & Dosage ♦ Humans ♦ Intensive Care Units ♦ Intubation, Intratracheal ♦ Adverse Effects ♦ Pneumonia, Ventilator-associated ♦ Physiopathology ♦ Therapy ♦ Virulence ♦ Journal Article ♦ Review
Abstract PURPOSE: Nosocomial rhinosinusitis (NS) is diagnosed in 2% to 26% of intubated patients and is associated with ventilator-associated pneumonia, septicemia, and fever of unknown etiology. The purpose of this study was to review the underlying pathogenetic mechanisms and the treatment options that derive from them. RESULT: The pathogenesis of NS seems to be mainly a combination of the failure of the local defenses and self-clearance mechanisms and the development of topical factors, which favor the colonization of the nasal and antral cavities with pathogens. The systemic administration of antibiotics, which are the current treatment of NS, have a limited, if any, effect on any of the above pathophysiologic mechanisms. However, the review of the literature demonstrates that the research on functionally orientated treatment options has been limited to the effect of orotracheal vs nasotracheal intubation. There are no clinical trials investigating the effect, which combinations of pathophysiology-based measures may have on the prevalence and treatment of NS and ventilator-associated pneumonia. CONCLUSION: An update of the pathogenetic mechanisms demonstrates that the prevention and treatment of nosocomial rhinosinusitis may expand well beyond the systemic administration of antibiotics.
Description Country affiliation: Greece
Author Affiliation: Riga M ( ENT Department University Hospital of Alexadroupolis, 68100 Dragana, Alexandroupolis, Greece.
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-03-01
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 25
Issue Number 1

Source: WHO-Global Index Medicus