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Author Koch, Alexander ♦ Sanson, Edouard ♦ Voigt, Sebastian ♦ Helm, Anita ♦ Trautwein, Christian ♦ Tacke, Frank
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Social problems & services; associations ♦ Social welfare problems & services ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Bacterial Infections and Mycoses ♦ Nutritional and Metabolic Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Hormones, Hormone Substitutes, and Hormone Antagonists ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons ♦ Health Care Facilities, Manpower, and Services ♦ Health Care
Subject Keyword Discipline Critical Care ♦ Adiponectin ♦ Blood ♦ Critical Illness ♦ Mortality ♦ Adolescent ♦ Adult ♦ Aged ♦ Aged, 80 And Over ♦ Biological Markers ♦ Body Mass Index ♦ Cytokines ♦ Diabetes Mellitus ♦ Female ♦ Hospital Mortality ♦ Humans ♦ Intensive Care Units ♦ Male ♦ Middle Aged ♦ Obesity ♦ Prospective Studies ♦ Risk Factors ♦ Sepsis ♦ Young Adult ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract PURPOSE: Adiponectin has been proposed as an important regulator of glucose metabolism influencing obesity and insulin resistance, which are important risk factors for the outcome of critically ill patients. Moreover, experimental models of inflammation suggest protective anti-inflammatory properties of adiponectin. We therefore investigated the potential pathogenic role and prognostic value of circulating adiponectin levels in critical illness. MATERIALS AND METHODS: One hundred seventy critically ill patients (122 with sepsis and 48 without sepsis) were prospectively studied at admission to the medical intensive care unit (ICU) and compared with 60 healthy controls. Patients' survival was followed for approximately 3 years. RESULTS: Adiponectin serum concentrations did not differ between healthy controls and critically ill patients, neither in patients with nor in patients without sepsis. However, patients with decompensated liver cirrhosis had significantly elevated serum adiponectin levels. Likewise to non-critically ill subjects, ICU patients with preexisting diabetes or obesity displayed significantly reduced circulating adiponectin. Inflammatory cytokines did not correlate with serum adiponectin. Interestingly, low adiponectin levels at ICU admission were an independent positive predictor of short-term and overall survival. CONCLUSIONS: Although serum concentrations did not differ in critically ill patients from controls, low adiponectin levels at admission to ICU have been identified as an independent predictor of survival.
Description Country affiliation: Germany
Author Affiliation: Koch A ( Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.)
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-04-01
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 26
Issue Number 2


Source: WHO-Global Index Medicus