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Author Négyessy, László ♦ Pálfi, Emese ♦ Ashaber, Mária ♦ Palmer, Cory ♦ Jákli, Balázs ♦ Friedman, Robert M. ♦ Chen, Li M. ♦ Roe, Anna W.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Computer science, information & general works ♦ Library & information sciences ♦ Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Incidence & prevention of disease ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Body Regions ♦ Nervous System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Heterocyclic Compounds ♦ Macromolecular Substances ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Psychological Phenomena and Processes ♦ Psychiatry and Psychology ♦ Cell Physiological Phenomena ♦ Biological Sciences ♦ Information Science ♦ Information Science
Subject Keyword Discipline Neurology ♦ Afferent Pathways ♦ Physiology ♦ Brain Mapping ♦ Somatosensory Cortex ♦ Anatomy & Histology ♦ Touch ♦ Action Potentials ♦ Animals ♦ Axons ♦ Biotin ♦ Analogs & Derivatives ♦ Metabolism ♦ Dextrans ♦ Female ♦ Fingers ♦ Innervation ♦ Image Processing, Computer-assisted ♦ Male ♦ Neuroimaging ♦ Neurons ♦ Ultrastructure ♦ Physical Stimulation ♦ Saimiri ♦ Journal Article ♦ Research Support, N.i.h., Extramural ♦ Research Support, Non-u.s. Gov't
Abstract To understand manual tactile functions in primates, it is essential to explore the interactions between the finger pad representations in somatosensory cortex. To this end, we used optical imaging and electrophysiological mapping to guide neuroanatomical tracer injections into distal digit tip representations of Brodmann area 3b in the squirrel monkey. Retrogradely labeled cell densities and anterogradely labeled fibers and terminal patches in somatosensory areas were plotted and quantified with respect to tangential distribution. Within area 3b, reciprocal patchy distribution of anterograde and retrograde labeling spanned the representation of the distal pad of multiple digits, indicating strong cross-digit connectivity. Inter-areal connections revealed bundles of long-range fibers projecting anteroposteriorly, connecting area 3b with clusters of labeled neurons and terminal axon arborizations in area 1. Inter-areal linkage appeared to be largely confined to the representation of the injected finger. These findings provide the neuroanatomical basis for the interaction between distal finger pad representations observed by recent electrophysiological studies. We propose that intra-areal connectivity may be heavily involved in interdigit integration such as shape discrimination, whereas long-range inter-areal connections may subserve active touch in a digit-specific manner.
Description Country affiliation: Hungary
Author Affiliation: Négyessy L ( Department of Theory, Institute for Particle and Nuclear Physics, Wigner Research Center for Physics, Hungarian Academy of Sciences, Budapest H-1121, Hungary. negyessy.laszlo@wigner.mta.hu)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-08-15
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 521
Issue Number 12


Source: WHO-Global Index Medicus