Thumbnail
Access Restriction
Subscribed

Author Park, Dong Won ♦ Kwak, Dong Shin ♦ Park, Yun Young ♦ Chang, Youjin ♦ Huh, Jin Won ♦ Lim, Chae-Man ♦ Koh, Younsuck ♦ Song, Dong-Keun ♦ Hong, Sang-Bum
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Social problems & services; associations ♦ Social welfare problems & services ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Bacterial Infections and Mycoses ♦ Diseases ♦ Hormones, Hormone Substitutes, and Hormone Antagonists ♦ Lipids ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Diagnosis ♦ Therapeutics ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons ♦ Health Care Facilities, Manpower, and Services ♦ Health Care
Subject Keyword Discipline Critical Care ♦ Lysophosphatidylcholines ♦ Blood ♦ Sepsis ♦ Mortality ♦ Apache ♦ Aged ♦ Biological Markers ♦ C-reactive Protein ♦ Analysis ♦ Calcitonin ♦ Calcitonin Gene-related Peptide ♦ Female ♦ Hospitalization ♦ Humans ♦ Intensive Care Units ♦ Lymphocyte Count ♦ Immunology ♦ Male ♦ Middle Aged ♦ Organ Dysfunction Scores ♦ Predictive Value Of Tests ♦ Prognosis ♦ Prospective Studies ♦ Protein Precursors ♦ Shock, Septic ♦ Time Factors ♦ Journal Article ♦ Observational Study ♦ Research Support, Non-u.s. Gov't
Abstract PURPOSE: The purpose of this study is to investigate the effect of serial lysophosphatidylcholine (LPC) measurement on 28-day mortality prediction in patients with severe sepsis or septic shock admitted to the medical intensive care unit (ICU). METHODS: This is a prospective observational study of 74 ICU patients in a tertiary hospital. Serum LPC, white blood cell, C-reactive protein, and procalcitonin (PCT) levels were measured at baseline (day 1 of enrollment) and day 7. The LPC concentrations were compared with inflammatory markers using their absolute levels and relative changes. RESULTS: The LPC concentration on day 7 was significantly lower in nonsurvivors than in survivors (68.45 ± 42.36 µmol/L and 99.76 ± 73.65 µmol/L; P = .04). A decreased LPC concentration on day 7 to its baseline as well as a sustained high concentration of PCT on day 7 at more than 50% of its baseline value was useful for predicting the 28-day mortality. Prognostic utility was substantially improved when combined LPC and PCT criteria were applied to 28-day mortality outcome predictions. Furthermore, LPC concentrations increased over time in patients with appropriate antibiotics but not in those with inappropriate antibiotics. CONCLUSIONS: Serial measurements of LPC help in the prediction of 28-day mortality in ICU patients with severe sepsis or septic shock.
Description Country affiliation: South Korea
Author Affiliation: Park DW ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.); Kwak DS ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.); Park YY ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.); Chang Y ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.); Huh JW ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.); Lim CM ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.); Koh Y ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.); Song DK ( Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, South Korea.); Hong SB ( Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: sbhong@amc.seoul.kr.)
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-10-01
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 29
Issue Number 5


Source: WHO-Global Index Medicus