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Author Rieger, K. E. ♦ Polidore, T. ♦ Warnke, R. ♦ Kim, J.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Body Regions ♦ Cardiovascular System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Neoplasms ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Enzymes and Coenzymes ♦ Chemicals and Drugs ♦ Diagnosis ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Pathology ♦ Discipline Dermatology ♦ Blood Vessels ♦ Pathology ♦ Lymphoma, Large-cell, Anaplastic ♦ Skin Neoplasms ♦ Aged ♦ Alkaline Phosphatase ♦ Metabolism ♦ Humans ♦ Immunohistochemistry ♦ Enzymology ♦ Male ♦ Neovascularization, Pathologic ♦ Scalp ♦ Blood Supply ♦ Case Reports ♦ Journal Article
Abstract Systemic cases of the CD30-positive T-cell neoplasm, anaplastic large cell lymphoma (ALCL), are typically anaplastic lymphoma kinase (ALK)-positive. The failure to express ALK protein has been shown to portend a worse prognosis. We describe a case of ALK-negative systemic ALCL that presented as a violaceous plaque on the scalp of a 79-year-old man. Interestingly, the neoplastic cells were confined largely within vascular spaces, a configuration that is exceedingly rare in the skin and is more typically seen with intravascular large B-cell lymphoma. In addition, bcl-2 immunohistochemical staining was strongly positive in this case, which may portend a more aggressive clinical course. To our knowledge, this report represents the first case of an ALK-negative ALCL to present intravascularly in the skin. Therefore, the recognition of systemic anaplastic T-cell lymphoma present within the intravascular spaces is important to avoid misdiagnosis.
Description Country affiliation: United States
Author Affiliation: Rieger KE ( Department of Dermatology, Stanford University, Stanford, CA 94305, USA.)
ISSN 03036987
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Case study ♦ Article
Publisher Date 2011-02-01
Publisher Place United States
e-ISSN 16000560
Journal Journal of Cutaneous Pathology
Volume Number 38
Issue Number 2


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Source: WHO-Global Index Medicus