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Author Reeves, Daniel B. ♦ Weaver, John B.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS ♦ BIOLOGICAL MARKERS ♦ CONCENTRATION RATIO ♦ HYPERTHERMIA ♦ LANGEVIN EQUATION ♦ MAGNETIZATION ♦ NANOPARTICLES ♦ NEOPLASMS ♦ SENSITIVITY ♦ SIMULATION ♦ THERAPY
Abstract Magnetic nanoparticles have been studied intensely because of their possible uses in biomedical applications. Biosensing using the rotational freedom of particles has been used to detect biomarkers for cancer, hyperthermia therapy has been used to treat tumors, and magnetic particle imaging is a promising new imaging modality that can spatially resolve the concentration of nanoparticles. There are two mechanisms by which the magnetization of a nanoparticle can rotate, a fact that poses a challenge for applications that rely on precisely one mechanism. The challenge is exacerbated by the high sensitivity of the dominant mechanism to applied fields. Here, we demonstrate stochastic Langevin equation simulations for the combined rotation in magnetic nanoparticles exposed to oscillating applied fields typical to these applications to both highlight the existing relevant theory and quantify which mechanism should occur in various parameter ranges.
ISSN 00036951
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-11-30
Publisher Place United States
Journal Applied Physics Letters
Volume Number 107
Issue Number 22


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