|Author||Zhang, Y. ♦ Li, T. ♦ Heron, D. ♦ Huq, M.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||APPLIED LIFE SCIENCES ♦ ALGORITHMS ♦ COLLIMATORS ♦ CONES ♦ CORRECTIONS ♦ IONIZATION CHAMBERS ♦ LEAST SQUARE FIT ♦ MONTE CARLO METHOD ♦ RADIATION DOSES ♦ RADIOTHERAPY|
|Abstract||Purpose: For small field dosimetry, such as measurements of output factors for cones or MLC-shaped irregular small fields, ion chambers often Result in an underestimation of the dose, due to both the volume averaging effect and the lack of lateral charged particle equilibrium. This work presents a mathematical model for correction matrix for a PTW PinPoint ionization chamber for dosimetric measurements made in the newly released Incise™ Multileaf collimator fields of the CyberKnife M6™ machine. Methods: A correction matrix for a PTW 0.015cc PinPoint ionization chamber was developed by modeling its 3D dose response in twelve cone-shaped circular fields created using the 5mm, 7.5mm, 10mm, 12.5mm, 15mm, 20mm, 25mm, 30mm, 35mm, 40mm, 50mm, 60mm cones in a CyberKnife M6™ machine. For each field size, hundreds of readings were recorded for every 2mm chamber shift in the horizontal plane. The contribution of each dose pixel to a measurement point depended on the radial distance and the angle to the chamber axis. These readings were then compared with the theoretical dose as obtained with Monte Carlo calculation. A penalized least-square optimization algorithm was developed to generate the correction matrix. After the parameter fitting, the mathematical model was validated for MLC-shaped irregular fields. Results: The optimization algorithm used for parameter fitting was stable and the resulted response factors were smooth in spatial domain. After correction with the mathematical model, the chamber reading matched with the calculation for all the tested fields to within 2%. Conclusion: A novel mathematical model has been developed for PinPoint chamber for dosimetric measurements in small MLC-shaped irregular fields. The correction matrix is dependent on detector, treatment unit and the geometry of setup. The model can be applied to non-standard composite fields and provides an access to IMRT point dose validation.|
|Learning Resource Type||Article|
|Publisher Place||United States|
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