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Author Arthur, Douglas W. ♦ Winter, Kathryn A. ♦ Kuerer, Henry M. ♦ Haffty, Bruce G. ♦ Cuttino, Laurie W. ♦ Todor, Dorin A. ♦ Simone, Nicole L. ♦ Hayes, Shelly B. ♦ Woodward, Wendy A. ♦ McCormick, Beryl ♦ Cohen, Randi J. ♦ Sahijdak, Walter M. ♦ Canaday, Daniel J. ♦ Brown, Doris R. ♦ Currey, Adam D. ♦ Fisher, Christine M.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ AUGER ELECTRON SPECTROSCOPY ♦ GY RANGE ♦ MAMMARY GLANDS ♦ NEOPLASMS ♦ PATIENTS ♦ RADIATION DOSES ♦ RADIATION HAZARDS ♦ SURGERY ♦ THREE-DIMENSIONAL CALCULATIONS ♦ TOXICITY
Abstract Purpose: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation. Methods and Materials: Eligibility criteria included in-breast recurrence occurring >1 year after whole-breast irradiation, <3 cm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade ≥3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring ≤1 year from re-treatment completion. A rate of ≥13% for these AEs in a cohort of 55 patients was determined to be unacceptable (86% power, 1-sided α = 0.07). Results: Between 2010 and 2013, 65 patients were accrued, and the first 55 eligible and with 1 year follow-up were analyzed. Median age was 68 years. Twenty-two patients had ductal carcinoma in situ, and 33 had invasive disease: 19 ≤1 cm, 13 >1 to ≤2 cm, and 1 >2 cm. All patients were clinically node negative. Systemic therapy was delivered in 51%. All treatment plans underwent quality review for contouring accuracy and dosimetric compliance. All treatment plans scored acceptable for tumor volume contouring and tumor volume dose-volume analysis. Only 4 (7%) scored unacceptable for organs at risk contouring and organs at risk dose-volume analysis. Treatment-related skin, fibrosis, and/or breast pain AEs were recorded as grade 1 in 64% and grade 2 in 7%, with only 1 (<2%) grade ≥3 and identified as grade 3 fibrosis of deep connective tissue. Conclusion: Partial-breast reirradiation with 3-dimensional conformal radiation therapy after second lumpectomy for patients experiencing in-breast failures after whole-breast irradiation is safe and feasible, with acceptable treatment quality achieved. Skin, fibrosis, and breast pain toxicity was acceptable, and grade 3 toxicity was rare.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-08-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 98
Issue Number 5


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