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Author Grove, D. I. ♦ Callaghan, S. J. O' ♦ Burston, T. O. ♦ Forbes, I. J.
Source British Medical Journal (The BMJ)
Content type Text
Publisher British Medical Journal Publishing Group
File Format HTM / HTML
Language English
Abstract Humoral and cellular immunity have been investigated in 15 patients with dystrophia myotonica. No abnormalities in total serum levels of the five major immunoglobulin classes were found but there was a rise in the mean serum level of β1A complement. Altogether, 54% of patients failed to make antibody to tetanus toxoid as compared with 1% of controls: 13% of patients failed to make antibody to Salmonella typhi H antigen as compared with no failure of this function in control subjects. There was a reduced uptake of tritiated thymidine by whole blood lymphocyte cultures spontaneously, while in the presence of phytohaemagglutinin (PHA) and both autologous and fetal calf serum the uptake was normal. It is suggested that there may be a wider derangement of immunological function in dystrophia myotonica than previously thought.
Description Citation Reference: British Medical Journal
ISSN 00071447
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Learning Resource Type Article
Publisher Date 1973-07-14
e-ISSN 14685833
Journal British Medical Journal (The BMJ)
Volume Number 3
Issue Number 5871
Page Count 3
Starting Page 81
Ending Page 83

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Source: British Medical Journal (The BMJ)