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Author Long, Ruiqi ♦ King, Travis ♦ Akl, Tony ♦ Ericson, Milton Nance ♦ Wilson, Mark A. ♦ Cote, Gerard L. ♦ McShane, Michael J.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BASIC BIOLOGICAL SCIENCES ♦ APPLIED LIFE SCIENCES ♦ ANIMALS ♦ APPROXIMATIONS ♦ DESIGN ♦ ELASTOMERS ♦ IMPLANTS ♦ LIVER ♦ MONITORING ♦ MONITORS ♦ OPTICAL PROPERTIES ♦ PERFUSED TISSUES ♦ PHANTOMS ♦ SENSORS ♦ TRANSPLANTS ♦ WAVELENGTHS
Abstract One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system.
ISSN 21567085
Educational Use Research
Learning Resource Type Article
Publisher Date 2011-01-01
Publisher Place United States
Journal Biomedical Optics Express
Volume Number 2
Issue Number 7
Organization Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)


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