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Author Tao, Yong ♦ Lin, Baixue
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher BioMed Central
File Format HTM / HTML
Date Created 2018-08-20
Copyright Year ©2017
Language English
Subject Domain (in LCC) QR1-502
Subject Keyword Cofactor balance ♦ Optimization ♦ Design ♦ Biosynthetic pathway ♦ Science ♦ Microbiology ♦ Metabolic engineering ♦ Whole-cell biocatalysis
Abstract Abstract Whole-cell biocatalysts provide unique advantages and have been widely used for the efficient biosynthesis of value-added fine and bulk chemicals, as well as pharmaceutically active ingredients. What is more, advances in synthetic biology and metabolic engineering, together with the rapid development of molecular genetic tools, have brought about a renaissance of whole-cell biocatalysis. These rapid advancements mean that whole-cell biocatalysts can increasingly be rationally designed. Genes of heterologous enzymes or synthetic pathways are increasingly being introduced into microbial hosts, and depending on the complexity of the synthetic pathway or the target products, they can enable the production of value-added chemicals from cheap feedstock. Metabolic engineering and synthetic biology efforts aimed at optimizing the existing microbial cell factories concentrate on improving heterologous pathway flux, precursor supply, and cofactor balance, as well as other aspects of cellular metabolism, to enhance the efficiency of biocatalysts. In the present review, we take a critical look at recent developments in whole-cell biocatalysis, with an emphasis on strategies applied to designing and optimizing the organisms that are increasingly modified for efficient production of chemicals.
ISSN 14752859
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2017-06-01
e-ISSN 14752859
Journal Microbial Cell Factories
Volume Number 16
Issue Number 1
Page Count 12
Starting Page 1
Ending Page 12


Source: Directory of Open Access Journals (DOAJ)