|Author||Rabee, Zeinab ♦ Abbaspoor, Zahra ♦ Najjar, Shahnaz|
|Source||Directory of Open Access Journals (DOAJ)|
|Publisher||Bharati Biomedical and Advance Research Centre|
|File Format||HTM / HTML|
|Subject Domain (in LCC)||RM1-950|
|Subject Keyword||Therapeutics ♦ Bacterial vaginosis ♦ Tinidazole ♦ Pharmacology ♦ Medicine ♦ Metronidazole|
|Abstract||Aims: Oral metronidazole 500 mg twice a day for one week is currently the treatment of choice for bacterial vaginosis (BV). Complete treatment by this regimen takes time and occurs less often. This drug has significant side effects too. Using a drug in the shortest treatment course may increases the success of treatment. To evaluate the effectiveness and safety of oral tinidazole compare to metronidazole in treatment of BV. Methods: In this randomized, controlled, double-blind, comparative, clinical trial, 110 non-pregnant women aged between 15-45 years with confirmed diagnosis of BV by Amsels criteria were randomly assigned to receive either 2 g tinidazole tablet once daily for 2 days (n=55) or 500 mg metronidazole table twice daily for 7 days (n=55).The cure and recurrence rate were evaluated in both groups after 2 and 4 weeks follow up visits. For statistical analysis t-test, test, fisher's exact test and Mann-Whitney test were used. Results: The results showed that cure rate after 2 weeks in tinidazole tablet group was 84.6? and in metronidazole group was 85.4? (p=0.9), and after 4 weeks recurrence rate in tinidazole and metronidazole groups was 6.9?and 12.1?respectively (P=0.3). Conclusions: Tinidazole table 2 g once daily for 2 days is as effective as metronidazole tablet 500 mg twice a day for 7 days in treatment of BV.|
|Age Range||18 to 22 years ♦ above 22 year|
|Education Level||UG and PG ♦ Career/Technical Study|
|Learning Resource Type||Article|
|Journal||International Journal of Pharmacological Research|
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