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Author Rabee, Zeinab ♦ Abbaspoor, Zahra ♦ Najjar, Shahnaz
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Bharati Biomedical and Advance Research Centre
File Format HTM / HTML
Date Created 2015-02-05
Copyright Year ©2014
Language English
Subject Domain (in LCC) RM1-950
Subject Keyword Therapeutics ♦ Bacterial vaginosis ♦ Tinidazole ♦ Pharmacology ♦ Medicine ♦ Metronidazole
Abstract Aims: Oral metronidazole 500 mg twice a day for one week is currently the treatment of choice for bacterial vaginosis (BV). Complete treatment by this regimen takes time and occurs less often. This drug has significant side effects too. Using a drug in the shortest treatment course may increases the success of treatment. To evaluate the effectiveness and safety of oral tinidazole compare to metronidazole in treatment of BV. Methods: In this randomized, controlled, double-blind, comparative, clinical trial, 110 non-pregnant women aged between 15-45 years with confirmed diagnosis of BV by Amsels criteria were randomly assigned to receive either 2 g tinidazole tablet once daily for 2 days (n=55) or 500 mg metronidazole table twice daily for 7 days (n=55).The cure and recurrence rate were evaluated in both groups after 2 and 4 weeks follow up visits. For statistical analysis t-test, test, fisher's exact test and Mann-Whitney test were used. Results: The results showed that cure rate after 2 weeks in tinidazole tablet group was 84.6? and in metronidazole group was 85.4? (p=0.9), and after 4 weeks recurrence rate in tinidazole and metronidazole groups was 6.9?and 12.1?respectively (P=0.3). Conclusions: Tinidazole table 2 g once daily for 2 days is as effective as metronidazole tablet 500 mg twice a day for 7 days in treatment of BV.
ISSN 22773312
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2014-05-01
e-ISSN 22773312
Journal International Journal of Pharmacological Research
Volume Number 4
Issue Number 2
Page Count 6
Starting Page 78
Ending Page 83


Source: Directory of Open Access Journals (DOAJ)