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Author Huber, S. E. ♦ Tanzer, K. ♦ Denifl, S. ♦ Śmiałek, M. A.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ♦ CHEMOTHERAPY ♦ DISSOCIATION ♦ ELECTRON ATTACHMENT ♦ EXPERIMENTAL DATA ♦ HYDROXYL RADICALS ♦ HYDROXYUREA ♦ MASS SPECTRA
Abstract Dissociative electron attachment to hydroxyurea was studied in the gas phase for electron energies ranging from zero to 9 eV in order to probe its radiosensitizing capabilities. The experiments were carried out using a hemispherical electron monochromator coupled with a quadrupole mass spectrometer. Diversified fragmentation of hydroxyurea was observed upon low energy electron attachment and here we highlight the major dissociation channels. Moreover, thermodynamic thresholds for various fragmentation reactions are reported to support the discussion of the experimental findings. The dominant dissociation channel, which was observed over a broad range of energies, is associated with formation of NCO{sup −}, water, and the amidogen (NH{sub 2}) radical. The second and third most dominant dissociation channels are associated with formation of NCNH{sup −} and NHCONH{sub 2}{sup −}, respectively, which are both directly related to formation of the highly reactive hydroxyl radical. Other ions observed with significant abundance in the mass spectra were NH{sub 2}{sup −}/O{sup −}, OH{sup −}, CN{sup −}, HNOH{sup −}, NCONH{sub 2}{sup −}, and ONHCONH{sub 2}{sup −}.
ISSN 00219606
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-06-14
Publisher Place United States
Journal Journal of Chemical Physics
Volume Number 144
Issue Number 22


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