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Author Yamada, Michiko ♦ Kodama, Kazunori ♦ Akahoshi, Masazumi
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE, APPLIED STUDIES ♦ A-BOMB SURVIVORS ♦ NEOPLASMS ♦ SKIN ♦ DOSIMETRY ♦ SKIN DISEASES ♦ CARCINOMAS
Abstract About 7,000 atomic bomb (A-bomb) survivors from Hiroshima and Nagasaki who participate in the Radiation Effects Research Foundation (RERF) Adult Health Study (AHS) were examined to define the relationship between skin neoplasms and exposure to ionizing radiation. Careful clinical inspection of the skin was undertaken to detect not only skin cancer but precancerous lesions such as senile keratosis. Five cases of basal cell carcinoma, five cases of senile keratosis and one case of Bowen`s disease were confirmed histologically among 5955 A-bomb survivors for whom Dosimetry System 1986 (DS86) dose estimates are available. The relationship between the combined prevalence of skin cancer and precancerous lesions and DS86 dose was examined together with other factors that might affect skin neoplasms including occupational exposure to ultraviolet (UV) rays, age, sex and city. The prevalence of basal cell carcinoma and senile keratosis increased as the DS86 dose increased. The prevalent of skin cancer and senile keratosis among persons engaged in work involving frequent exposure to UV rays was higher than among those who were not engaged in such work. Sex and city were not significantly related to those skin diseases. Odds ratios of skin neoplasm for a 1-Gy dose, occupational exposure to UV rays and age at time of examination exposure to UV rays and age at time of examination (in 10-year increments) are 1.7, 5.9 and 1.9, respectively. 22 refs., 3 tabs.
ISSN 00337587
Educational Use Research
Learning Resource Type Article
Publisher Date 1996-08-01
Publisher Place United States
Journal Radiation Research
Volume Number 146
Issue Number 2


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