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Author Chak, Eric ♦ Matsukuma, Karen ♦ Chew, Michael tsuyoshi
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Karger Publishers
File Format HTM / HTML
Date Created 2016-11-04
Copyright Year ©2016
Language English
Subject Domain (in LCC) RC799-869
Subject Keyword Pulmonary nodules ♦ Extraintestinal manifestations ♦ Internal medicine ♦ Diseases of the digestive system ♦ Medicine ♦ Gastroenterology ♦ Crohn’s disease ♦ Specialties of internal medicine
Abstract Crohn’s disease is a chronic, idiopathic autoimmune disorder that primarily targets the gastrointestinal (GI) system. It is characterized by transmural inflammation of the GI tract that can occur anywhere from the mouth to the anus. Not infrequently, the disease may also have extraintestinal manifestations (EIMs) that can affect almost any organ system. It is estimated that EIMs affect up to 36% of patients with Crohn’s disease, but the incidence and prevalence of pulmonary involvement are variable in the literature and may be as low as 0.4%. There are few case reports documenting pulmonary manifestations, as they are often overlooked, especially if respiratory symptoms are present before the diagnosis of GI manifestations, as in the present case. A 44-year-old otherwise healthy woman presented with nonspecific respiratory complaints, recurrent pneumonias, and multiple computed tomography images showing diffuse, migratory, nodular, and consolidative parenchymal lung disease, with a largely unremarkable infectious and rheumatologic evaluation. Lung biopsy revealed necrotizing and nonnecrotizing granulomas, raising concern for sarcoidosis. Subsequent imaging revealed an incidental mass in the cecum. Biopsy of the cecum lesion revealed acute cryptitis, crypt abscess, and a single poorly formed granuloma, suggesting the possibility of Crohn’s disease. In this report, we present a patient whose pulmonary manifestations ultimately led to the diagnosis of Crohn’s disease.
ISSN 16620631
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2016-10-01
e-ISSN 16620631
Journal Case Reports in Gastroenterology
Volume Number 10
Issue Number 3
Page Count 7
Starting Page 633
Ending Page 639

Source: Directory of Open Access Journals (DOAJ)