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Author Takikawa, Yasuhiro ♦ Suzuki, Kazuyuki ♦ Mizutani, Tomomi ♦ Endo, Masaki ♦ Chiba, Toshimi ♦ Fujiwara, Saori ♦ Kudara, Norihiko ♦ Tomita, Kazumitsu ♦ Akasaka, Risaburo ♦ Chowdhury, Manzurul ♦ Sugai, Tamotsu
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Karger Publishers
File Format HTM / HTML
Date Created 2016-08-17
Copyright Year ©2009
Language English
Subject Domain (in LCC) RC799-869
Subject Keyword Double-balloon endoscopy ♦ Infliximab ♦ Internal medicine ♦ Diseases of the digestive system ♦ Medicine ♦ Gastroenterology ♦ Specialties of internal medicine ♦ Gastrointestinal bleeding ♦ Crohn's disease
Abstract Tumor necrosis factor α plays an important role in the pathogenesis of Crohn’s disease (CD). The effects of infliximab on gastrointestinal bleeding in CD have not yet been fully evaluated. Herein we describe three CD cases who presented with gastrointestinal bleeding and received infliximab treatment. In case 1, double-balloon endoscopy showed a large ulcer with several irregularly shaped ulcers in the terminal ileum; 8 weeks after infliximab administration, complete healing of all lesions was observed. In case 2, double-balloon endoscopy showed linear ulcers and mucosal edema in the jejunum and ileum; 5 weeks after infliximab administration, all lesions were decreased in size and were healed. In case 3, double-balloon endoscopy revealed ulcerations and stenosis in the terminal ileum; 12 weeks after infliximab administration, ulcer healing and an increased diameter of the ileal stenosis were observed. These three cases have been receiving ongoing infliximab maintenance therapy and are currently symptom-free. Infliximab thus appears to be useful for treatment of gastrointestinal bleeding in CD patients.
ISSN 16620631
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2009-07-01
e-ISSN 16620631
Journal Case Reports in Gastroenterology
Volume Number 3
Issue Number 2
Page Count 5
Starting Page 193
Ending Page 197


Source: Directory of Open Access Journals (DOAJ)