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Author Salam, Tariqus ♦ Sawan, Mohamad ♦ Nguyen, Dang Khoa
Source ACM Digital Library
Content type Text
Publisher Association for Computing Machinery (ACM)
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Neural signal recording ♦ Current stimulation ♦ Low-power CMOS circuits ♦ Voltage distribution in brain tissues
Abstract In this article, we present an implantable closed-loop epilepsy prosthesis, which is dedicated to automatically detect seizure onsets based on intracerebral electroencephalographic (icEEG) recordings from intracranial electrode contacts and provide an electrical stimulation feedback to the same contacts in order to disrupt these seizures. A novel epileptic seizure detector and a dedicated electrical stimulator were assembled together with common recording electrodes to complete the proposed prosthesis. The seizure detector was implemented in CMOS $0.18-\textit{μ}m$ by incorporating a new seizure detection algorithm that models time-amplitude and -frequency relationship in icEEG. The detector was validated offline on ten patients with refractory epilepsy and showed excellent performance for early detection of seizures. The electrical stimulator, used for suppressing the developing seizure, is composed of two biphasic channels and was assembled with embedded FPGA in a miniature PCB. The stimulator efficiency was evaluated on cadaveric animal brain tissue in an in vitro morphologic electrical model. Spatial characteristics of the voltage distribution in cortex were assessed in an attempt to identify optimal stimulation parameters required to affect the suspected epileptic focus. The experimental results suggest that lower frequency stimulation parameters cause significant amount of shunting of current through the cerebrospinal fluid; however higher frequency stimulation parameters produce effective spatial voltage distribution with lower stimulation charge.
ISSN 15504832
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-06-01
Publisher Place New York
e-ISSN 15504840
Journal ACM Journal on Emerging Technologies in Computing Systems (JETC)
Volume Number 8
Issue Number 2
Page Count 18
Starting Page 1
Ending Page 18


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Source: ACM Digital Library