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Author Abebe, Nardos ♦ Kebede, Tedla ♦ Wolde, Mistire
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher African Field Epidemiology Network
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Male Urogenital Diseases ♦ Endocrine System Diseases ♦ Diseases ♦ Inorganic Chemicals ♦ Hormones, Hormone Substitutes, and Hormone Antagonists ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons ♦ Geographic Locations ♦ Geographic Locations
Subject Keyword Discipline Medicine ♦ Kidney Diseases ♦ Epidemiology ♦ Thyroid Diseases ♦ Physiopathology ♦ Thyroid Hormones ♦ Metabolism ♦ Water-electrolyte Balance ♦ Physiology ♦ Adolescent ♦ Adult ♦ Cross-sectional Studies ♦ Electrolytes ♦ Ethiopia ♦ Female ♦ Humans ♦ Kidney Function Tests ♦ Logistic Models ♦ Male ♦ Middle Aged ♦ Questionnaires ♦ Complications ♦ Thyroid Function Tests ♦ Young Adult ♦ Journal Article
Abstract INTRODUCTION: Studies demonstrated that abnormal thyroid functions may result in decreased or increased kidney size, kidney weight, and affect renal functions. In this regard, studies on the association of abnormal thyroid functions and renal function tests are scarcely found in Ethiopia. OBJECTIVE: To assess renal function and electrolytes in patients with thyroid dysfunction, in Addis Ababa, Ethiopia. METHODS: Cross sectional study was conducted from March 21/2015-May 27/2015 at Arsho Advanced Medical Laboratory. During the study period, 71 patients with thyroid dysfunction were eligible, and socio demographic data collected by structured questionnaire. Then blood sample was collected for thyroid function tests, renal function and blood electrolyte analysis. The collected data was analyzed by SPSS version 20. ANOVA and binary logistic regression were employed to evaluate the mean deference and associations of thyroid hormone with renal function and electrolyte balances. RESULTS: Among the renal function tests, serum uric acid, and creatinine mean values were significantly decreased in hyperthyroid patients; whereas, eGFR mean value was significantly increased in hyperthyroid study patients (P<0.05). Meanwhile, from the electrolyte measurements made, only the mean serum sodium value was significantly increased in hyperthyroid study participants. Binary logistic regression analysis on the association of thyroid dysfunction with electrolyte balance and renal function tests indicated that serum sodium, creatinine, eGFR values and hyperthyroidism have a statistical significant association at AOR 95% CI of 0.141(0.033-0.593, P=0.008); 16.236(3.481-75.739, P=0.001), and 13.797(3.261-58.67, P=0.001) respectively. CONCLUSION: The current study reveals, thyroid abnormalities may lead to renal function alterations and also may disturb electrolyte balance. Knowledge of this significant association has worthwhile value for clinicians, to manage their patients' optimally.
Spatial Coverage Ethiopia
Description Country affiliation: Ethiopia
Author Affiliation: Abebe N ( Bethzatha Advanced Medical Laboratory and Registered Assessor of ISO 15189, Addis Abeba, Ethiopia.); Kebede T ( Department of Internal medicine, College of Health Science, Addis Abeba University, Ethiopia.); Wolde M ( Department of Medical Laboratory Sciences, College of Health Science, Addis Abeba University, Ethiopia.)
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-01-01
Publisher Place Uganda
e-ISSN 19378688
Journal Pan African Medical Journal
Volume Number 24


Source: WHO-Global Index Medicus