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Author Serragui, Samira ♦ Zalagh, Fatima ♦ Tanani, Driss Soussi ♦ Ouammi, Lahcen ♦ Moussa, Latifa Ait ♦ Badrane, Narjis ♦ Bencheikh, Rachida Soulaymani
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher African Field Epidemiology Network
File Format HTM / HTML
Language French
Difficulty Level Medium
Alternative Title Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience
Subject Domain (in DDC) Technology ♦ Medicine & health
Abstract INTRODUCTION: The therapeutic drug monitoring (TDM) of antiepileptic drugs is a tool widely used in the management of epilepsy. In Morocco, this monitoring is carried out by the Centre Anti Poison et Pharmacovigilance (CAPM) since April 1995. METHODS: This is a retrospective study spanning 20 years. It concerns the therapeutic drug monitoring of Phenobarbital (PB) of carbamazepine (CBZ) and valproic acid (VPA). RESULTS: Therapeutic drug monitoring of the 3 antiepileptic drugs represent 58.85% of all applications received by the CAPM. The dosage of PB was ranked first followed by that of CBZ and finally by the VPA. Weak demand for therapeutic drug monitoring in Morocco could be explained by the low number of neurologists in addition to social factors. With its affordable price by patients, PB is the most prescribed antiepileptic drug in our country, which explains the high demand for its dosage. As for the therapeutic drug monitoring of the antiepileptic drug, they were mainly related to age, the occurrence of adverse effects, the association antiepileptic drugs or in the case of verification of patient compliance. CONCLUSION: Efforts are required for promoting the interests of therapeutic drug monitoring of antiepileptic drug in the management of epilepsy in Morocco.
Description Country affiliation: Morocco
Author Affiliation: Serragui S ( Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.); Zalagh F ( Centre Anti Poison et de Pharmacovigilance du Maroc.); Tanani DS ( Laboratoire de Pharmacologie Faculté de Médecine et de Pharmacie, Université Abdelmalek Essaadi, Tanger, Maroc.); Ouammi L ( Centre Anti Poison et de Pharmacovigilance du Maroc.); Moussa LA ( Centre Anti Poison et de Pharmacovigilance du Maroc.); Badrane N ( Centre Anti Poison et de Pharmacovigilance du Maroc.); Bencheikh RS ( Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc)
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-01-01
Publisher Place Uganda
e-ISSN 19378688
Journal Pan African Medical Journal
Volume Number 25


Source: WHO-Global Index Medicus