Thumbnail
Access Restriction
Open

Author Archampong, Timothy Nii Akushe ♦ Asmah, Richard Harry ♦ Wiredu, Edwin Kwame ♦ Gyasi, Richard Kwasi ♦ Nkrumah, Kofi Nyaako ♦ Rajakumar, Kumar
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher African Field Epidemiology Network
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Sociology & anthropology ♦ Social groups ♦ Natural sciences & mathematics ♦ Life sciences; biology ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Bacteria ♦ Organisms ♦ Bacterial Infections and Mycoses ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Social Sciences ♦ Anthropology, Education, Sociology and Social Phenomena ♦ Persons ♦ Persons ♦ Population Characteristics ♦ Health Care ♦ Geographic Locations ♦ Geographic Locations
Subject Keyword Discipline Medicine ♦ Dyspepsia ♦ Epidemiology ♦ Helicobacter Infections ♦ Helicobacter Pylori ♦ Isolation & Purification ♦ Adult ♦ Age Distribution ♦ Aged ♦ Biopsy ♦ Cross-sectional Studies ♦ Microbiology ♦ Employment ♦ Statistics & Numerical Data ♦ Endoscopy, Gastrointestinal ♦ Farmers ♦ Female ♦ Ghana ♦ Humans ♦ Incidence ♦ Male ♦ Middle Aged ♦ Prevalence ♦ Young Adult ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract INTRODUCTION: Helicobacter pylori is a gram-negative urease-producing bacterium causally linked with gastritis, peptic ulcer disease and gastric adenocarcinoma. Infection is more frequent and acquired at an earlier age in developing countries compared to European populations. The incidence of Helicobacter pylori infection in dyspeptic Ghanaian patients was 75.4%. However, epidemiological factors associated with infection vary across populations. METHODS: This study used a cross-sectional design to consecutively sample dyspeptic patients at the Endoscopy Unit of the Korle-Bu Teaching Hospital, Accra between 2010 and 2012. The study questionnaire elicited their epidemiological clinical characteristics. Helicobacter pylori infection was confirmed by rapid-urease examination of antral biopsies at upper Gastro-intestinal endoscopy. RESULTS: The sample population of dyspeptic patients attending the Endoscopy Unit for upper GI endoscopy yielded 242 patients of which 47.5% were females. The age distribution of H. pylori-infection was even across most age - groups, ranging from 69.2% (61 - 70) years to 80% (21 - 30) years. Helicobacter pylori prevalence decreased across areas mapping to the three residential classes in accordance with increasing affluence with rural areas having the highest prevalence. The unemployed and patients in farming had relatively high Helicobacter pylori infection rates of 92.3% and 91.7% respectively. CONCLUSION: Helicobacter pylori is endemic in Ghana but the persistently high prevalence across age groups despite significant community anti-microbial use suggests likely recrudescence or re-infection from multiple sources in a developing country. Socio-cultural factors such as residential class and farming may be facilitating factors for its continued prevalence.
Spatial Coverage Ghana
Description Country affiliation: Ghana
Author Affiliation: Archampong TN ( Department of Medicine, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon Boundary, Accra, Ghana.); Asmah RH ( Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Legon Boundary, Accra, Ghana.); Wiredu EK ( Department of Pathology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon Boundary, Accra, Ghana.); Gyasi RK ( Department of Pathology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon Boundary, Accra, Ghana.); Nkrumah KN ( Department of Medicine, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon Boundary, Accra, Ghana.); Rajakumar K ( Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester LE1 9HN, United Kingdom )
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-01-01
Publisher Place Uganda
e-ISSN 19378688
Journal Pan African Medical Journal
Volume Number 20


Source: WHO-Global Index Medicus