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Author Hsieh, Meng-Chang ♦ Chiu, Yi-Hsin ♦ Lin, Sheng-Fu ♦ Chang, Jenq-Yang ♦ Chang, Chia-Ou ♦ Chiang, Huihua Kenny
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Multidisciplinary Digital Publishing Institute
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Biological Sciences ♦ Natural Science Disciplines ♦ Physical Sciences
Subject Keyword Discipline Biotechnology ♦ Biosensing Techniques ♦ Methods ♦ Fiber Optic Technology ♦ Fluorescence ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract Fluorescent biosensors have been widely used in biomedical applications. To amplify the intensity of fluorescence signals, this study developed a novel structure for an evanescent wave fiber-optic biosensor by using a Fabry-Perot resonator structure. An excitation light was coupled into the optical fiber through a laser-drilled hole on the proximal end of the resonator. After entering the resonator, the excitation light was reflected back and forth inside the resonator, thereby amplifying the intensity of the light in the fiber. Subsequently, the light was used to excite the fluorescent molecules in the reactive region of the sensor. The experimental results showed that the biosensor signal was amplified eight-fold when the resonator reflector was formed using a 92% reflective coating. Furthermore, in a simulation, the biosensor signal could be amplified 20-fold by using a 99% reflector.
Description Country affiliation: Taiwan
Author Affiliation: Hsieh MC ( Institute of Applied Mechanics, National Taiwan University, 1 Sec.4 Roosevelt Road, Taipei 10617, Taiwan. yihsinchiu07@gmail.com.); Chiu YH ( Institute of Biomedical Engineering, National Yang-Ming University, No.155, Sec.2 Linong Street, Taipei 11221, Taiwan. yihsinchiu07@gmail.com.); Lin SF ( Institute of Biomedical Engineering, National Yang-Ming University, No.155, Sec.2 Linong Street, Taipei 11221, Taiwan. yihsinchiu07@gmail.com.); Chang JY ( Department of Optics and Photonics, National Central University, Jhongli 32001, Taiwan. 982406004@cc.ncu.edu.tw.); Chang CO ( Department of Optics and Photonics, National Central University, Jhongli 32001, Taiwan. jychang@dop.ncu.edu.tw.); Chiang HK ( Institute of Applied Mechanics, National Taiwan University, 1 Sec.4 Roosevelt Road, Taipei 10617, Taiwan. changco@iam.ntu.edu.tw.)
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-02-04
Publisher Place Switzerland
e-ISSN 14248220
Journal Sensors
Volume Number 15
Issue Number 2


Source: WHO-Global Index Medicus