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Author Sezai, Akira ♦ Osaka, Shunji ♦ Yaoita, Hiroko ♦ Arimoto, Munehito ♦ Hata, Hiroaki ♦ Shiono, Motomi ♦ Sakino, Hisakuni
Source J-STAGE
Content type Text
Publisher The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
Language English
Subject Keyword angiotensin ♦ aldosterone ♦ angiotensin II receptor blocker ♦ hypertension
Abstract Background: Angiotensin II receptor blockers (ARBs) have been widely used to treat hypertension and large-scale clinical studies have shown various benefits. In this study, we compared olmesartan with azilsartan, the newest ARB.Methods: The subjects were outpatients who were clinically stable after cardiac surgery. Sixty patients were randomized to receive either azilsartan or olmesartan for 1 year and were switched to the other drug for the following 1 year. The primary endpoints were the levels of plasma renin activity, angiotensin II, and aldosterone. Results: Home blood pressure exceeded 140/90 mmHg and additional antihypertensive medication was administered to 12 patients (20 episodes) in the azilsartan group versus 4 patients (4 episodes) in the olmesartan group, with the number being significantly higher in the azilsartan group. After 1 year of treatment, both angiotensin II and aldosterone levels were significantly lower in the olmesartan group than the azilsartan group. Left ventricular mass index was also significantly lower in the olmesartan group than the azilsartan group.Conclusion: This study showed that olmesartan reduces angiotensin II and aldosterone levels more effectively than azilsartan. Accordingly, it may be effective in patients with increased renin-angiotensin-aldosterone system activity after cardiac surgery or patients with severe cardiac hypertrophy.
ISSN 13411098
Learning Resource Type Article
Publisher Date 2016-01-01
e-ISSN 21861005
Journal Annals of Thoracic and Cardiovascular Surgery(atcs)
Volume Number 22
Issue Number 3
Page Count 7
Starting Page 161
Ending Page 167


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