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Author Kim, Manbok ♦ Rahman, Masmudur M. ♦ Cogle, Christopher R. ♦ McFadden, Grant
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ AIDS VIRUS ♦ BONE MARROW ♦ CARCINOMAS ♦ HUMAN POPULATIONS ♦ IN VIVO ♦ LEUKEMIA ♦ LYMPHOMAS ♦ MICE ♦ MUSCLES ♦ NATURAL KILLER CELLS ♦ PATIENTS ♦ THERAPY ♦ TRANSPLANTS
Abstract Epstein–Barr virus (EBV) has been associated with a variety of epithelial and hematologic malignancies, including B-, T- and NK cell-lymphomas, Hodgkin's disease (HD), post-transplant lymphoproliferative diseases (LPDs), nasopharyngeal and gastric carcinomas, smooth muscle tumors, and HIV-associated lymphomas. Currently, treatment options for EBV-associated malignancies are limited. We have previously shown that myxoma virus specifically targets various human solid tumors and leukemia cells in a variety of animal models, while sparing normal human or murine tissues. Since transplant recipients of bone marrow or solid organs often develop EBV-associated post-transplant LPDs and lymphoma, myxoma virus may be of utility to prevent EBV-associated malignancies in immunocompromised transplant patients where treatment options are frequently limited. In this report, we demonstrate the safety and efficacy of myxoma virus purging as a prophylactic strategy for preventing post-transplant EBV-transformed human lymphomas, using a highly immunosuppressed mouse xenotransplantation model. This provides support for developing myxoma virus as a potential oncolytic therapy for preventing EBV-associated LPDs following transplantation of bone marrow or solid organ allografts. - Highlights: • Myxoma virus effectively infects and purges EBV lymphoma cells in vivo. • Oncolytic myxoma virus effectively eradicates oncogenic EBV tumorigenesis. • Ex vivo pre-treatment of myxoma virus can be effective as a preventive treatment modality for post-transplant lymphoproliferative diseases.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-07-10
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 462
Issue Number 4


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