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Author Lindzey, Jonathan ♦ Wetsel, William C. ♦ Couse, John F. ♦ Stoker, Tammy ♦ Cooper, Ralph ♦ Korach, Kenneth S.
Source Paperity
Content type Text
Publisher Oxford University Press
File Format PDF ♦ HTM / HTML
Copyright Year ©1998
Abstract Testicular androgens are integral components of the hormonal feedback loops that regulate circulating levels of LH and FSH. The sites of feedback include hypothalamic areas regulating GnRH neurons and pituitary gonadotropes. To better define the roles of androgen receptor (AR), estrogen receptor-α (ERα), and estrogen receptor-β (ERβ) in mediating feedback effects of sex steroids on reproductive neuroendocrine function, we have determined the effects of castration and steroid replacement therapy on hypothalamic GnRH content, pituitary LHβ and FSHβ messenger RNA (mRNA) levels, and serum gonadotropins in male wild-type (WT) and estrogen receptor-α knockout (ERKO) mice. Hypothalami from intact WT and ERKO males contained similar amounts of GnRH, whereas castration significantly reduced GnRH contents in both genotypes. Replacement therapy with estradiol (E2), testosterone (T), or dihydrotestosterone (DHT) restored hypothalamic GnRH content in castrated (CAST) WT mice; only the androgens were effective in CAST ERKOs.
Learning Resource Type Article
Publisher Date 1998-10-01
Journal Endocrinology
Volume Number 139
Issue Number 10