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Author Fan, Rui ♦ Zhu, Fubao ♦ Hao, Lingmei ♦ Gu, Tianlun ♦ Zhang, Lina ♦ Mao, Shuqi ♦ Zhong, Fade ♦ Yin, Fengying
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Hindawi Limited
File Format HTM / HTML
Date Created 2017-01-03
Copyright Year ©2016
Language English
Subject Domain (in LCC) R
Subject Keyword Medicine
Abstract Aldosterone synthase (CYP11B2) is closely linked to essential hypertension (EH). However, it remains unclear whether the methylation of the CYP11B2 promoter is involved in the development of EH in humans. Our study is aimed at evaluating the contribution of CYP11B2 promoter methylation to the risk of EH. Methylation levels were measured using pyrosequencing technology in 192 participants in a hospital-based case-control study. Logistic regression and multiple linear regression analyses were utilized to adjust for confounding factors and the GMDR method was applied to investigate high-order gene-environment interactions. Although no significant result was observed linking the four analyzed CpG sites to EH, GMDR detected significant interactions among CpG1, CpG3, CpG4, and smoking correlated with an increased risk of EH (OR = 4.62, adjusted P=0.011). In addition, CpG2 (adjusted P=0.013) and CpG3 (adjusted P=0.039) methylation was significantly lower in healthy males than in healthy females. Likewise, after adjusting for confounding factors, CpG2 methylation (adjusted P=0.007) still showed significant gender-specific differences among the participants of the study. CpG1 (P=0.009) site was significantly positively correlated with age, and CpG3 (P=0.007) and CpG4 (P=0.006) were both inversely linked to smoking. Our findings suggest that gene-environment interactions are associated with the pathogenesis and progression of EH.
ISSN 23146133
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2016-01-01
e-ISSN 23146133
Journal BioMed Research International
Volume Number 2016

Source: Directory of Open Access Journals (DOAJ)