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Author Tsou, Yung-An ♦ Tsai, Ming-Hsui ♦ Chang, Wen-Dien ♦ Chen, Hsiao-Ling ♦ Chen, Chuan-Mu ♦ Alexander, Katherine A. ♦ Tung, Min-Che
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Hindawi Limited
File Format HTM / HTML
Date Created 2018-09-17
Copyright Year ©2018
Language English
Subject Domain (in LCC) R
Subject Keyword Medicine
Abstract The mucosa is part of the first line of immune defense against pathogen exposure in humans and prevents viral and bacterial infection of the soft palate, lungs, uvula, and nasal cavity that comprise the ear-nose-throat (ENT) region. Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases. This review will provide a brief introduction of the roles of BPIFA1 in the upper airway (with a focus on the nasal cavity, sinus, and middle ear), specifically its history, identification, distribution in various human tissues, function, and diagnostic value in various upper airway infectious diseases.
ISSN 23146133
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2018-01-01
e-ISSN 23146133
Journal BioMed Research International
Volume Number 2018


Source: Directory of Open Access Journals (DOAJ)