|Author||Guo, Li ♦ Yu, Jiafeng ♦ Zhao, Yang ♦ Xu, Changqing ♦ Chen, Feng ♦ Yu, Hao ♦ Chen, Shujie|
|Source||Directory of Open Access Journals (DOAJ)|
|File Format||HTM / HTML|
|Subject Domain (in LCC)||R|
|Abstract||We mainly discussed miR-#-5p and miR-#-3p under three aspects: (1) primary evolutionary analysis of human miRNAs; (2) evolutionary analysis of miRNAs from different arms across the typical 10 vertebrates; (3) expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets. We found that no bias can be detected between the numbers of 5p-miRNA and 3p-miRNA, while miRNAs from miR-#-5p and miR-#-3p show variable nucleotide compositions. IsomiR expression profiles from the two arms are always stable, but isomiR expressions in diseased samples are prone to show larger degree of dispersion. miR-#-5p and miR-#-3p have relative independent evolution/expression patterns and datasets of target mRNAs, which might also contribute to the phenomena of arm selection and/or arm switching. Simultaneously, miRNA/isomiR expression profiles may be regulated via arm selection and/or arm switching, and the dynamic miRNAome and isomiRome will adapt to functional and/or evolutionary pressures. A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study.|
|Age Range||18 to 22 years ♦ above 22 year|
|Education Level||UG and PG ♦ Career/Technical Study|
|Learning Resource Type||Article|
|Journal||BioMed Research International|
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