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Author Yunxiang, E. ♦ Chen, Guangxia ♦ Qin, Xiaobin ♦ Chen, Yuanyuan ♦ Hu, Ankang ♦ Mou, Jie ♦ Wu, Xiaojin ♦ Wang, Weitao ♦ Wang, Jindong ♦ Yuan, Dawei ♦ Cui, Jinpeng ♦ Liu, Xiangqun ♦ Mi, Yanyan ♦ Pei, Dongsheng ♦ Yu, Tao
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Hindawi Limited
File Format HTM / HTML
Date Created 2018-02-08
Copyright Year ©2018
Language English
Subject Domain (in LCC) R
Subject Keyword Medicine
Abstract Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.
ISSN 23146133
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2018-01-01
e-ISSN 23146133
Journal BioMed Research International
Volume Number 2018

Source: Directory of Open Access Journals (DOAJ)