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Author Hyun, Dongho ♦ Cho, Sung Ki ♦ Shin, Sung Wook ♦ Park, Kwang Bo ♦ Park, Hong Suk ♦ Choo, Sung Wook ♦ Do, Young Soo ♦ Choo, In-wook ♦ Lee, Min Woo ♦ Rhim, Hyunchul ♦ Lim, Hyo Keun
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ABLATION ♦ COMBINED THERAPY ♦ COMPARATIVE EVALUATIONS ♦ HAZARDS ♦ HEPATOMAS ♦ MULTIVARIATE ANALYSIS ♦ PATIENTS ♦ RADIOWAVE RADIATION
Abstract PurposeTo report the results of combined therapy with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC) considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE monotherapy.MethodsFrom January 2007 through December 2010, 91 patients with early or very early stage HCC infeasible for US-guided RFA received either TACE alone (TACE group; n = 54) or TACE immediately followed by RFA (TACE–RFA group; n = 37) as a first-line treatment. 1-month tumor response, time to progression (TTP), and overall survival (OS) rates were calculated. Univariate and multivariate analyses were performed to identify prognostic factors.ResultsTACE–RFA group showed a better 1-month tumor response than TACE group (P < .001). The mean TTP was 29.7 ± 3.4 months (95 % confidence intervals [CIs] 23.0–36.5) in TACE group and 34.9 ± 2.8 months (95 % CIs 29.4–40.4) in TACE–RFA group. TACE–RFA group had a significantly longer TTP (P = .014). Cumulative 1-, 2-, and 3-year OS rates in the TACE and TACE–RFA groups were 91, 79, and 71 % and 100, 97, and 93 %, respectively (P = .008). Initial treatment of TACE was found to be the only significant risk factor for tumor progression and OS in multivariate analysis.ConclusionTACE–RFA combination therapy appears superior to TACE monotherapy in terms of 1-month tumor response, TTP, and OS when performed for early stage HCC infeasible for US-guided RFA.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-03-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 39
Issue Number 3


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