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Author Mattsson, Charlotte L. ♦ Csikasz, Robert I. ♦ Chernogubova, Ekaterina ♦ Yamamoto, Daniel L. ♦ Hogberg, Helena T. ♦ Amri, Ez-Zoubir ♦ Hutchinson, Dana S. ♦ Bengtsson, Tore
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher American Physiological Society
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Genetics and evolution ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Physical Phenomena ♦ Chemical Phenomena ♦ Cell Physiological Phenomena ♦ Genetic Phenomena ♦ Physiological Phenomena ♦ Biological Sciences
Subject Keyword Discipline Physiology ♦ Discipline Metabolism ♦ Discipline Endocrinology ♦ Acclimatization ♦ Genetics ♦ Adipocytes, Brown ♦ Metabolism ♦ Ion Channels ♦ Mitochondrial Proteins ♦ Receptors, Adrenergic, Beta-1 ♦ Physiology ♦ Receptors, Adrenergic, Beta-3 ♦ Thermogenesis ♦ Cytology ♦ Animals ♦ Cell Differentiation ♦ Cells, Cultured ♦ Cold Temperature ♦ Down-regulation ♦ Epistasis, Genetic ♦ Female ♦ Humans ♦ Male ♦ Mice ♦ Mice, Knockout ♦ Multipotent Stem Cells ♦ Shivering ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract With the finding that brown adipose tissue is present and negatively correlated to obesity in adult man, finding the mechanism(s) of how to activate brown adipose tissue in humans could be important in combating obesity, type 2 diabetes, and their complications. In mice, the main regulator of nonshivering thermogenesis in brown adipose tissue is norepinephrine acting predominantly via ß(3)-adrenergic receptors. However, vast majorities of ß(3)-adrenergic agonists have so far not been able to stimulate human ß(3)-adrenergic receptors or brown adipose tissue activity, and it was postulated that human brown adipose tissue could be regulated instead by ß(1)-adrenergic receptors. Therefore, we have investigated the signaling pathways, specifically pathways to nonshivering thermogenesis, in mice lacking ß(3)-adrenergic receptors. Wild-type and ß(3)-knockout mice were either exposed to acute cold (up to 12 h) or acclimated for 7 wk to cold, and parameters related to metabolism and brown adipose tissue function were investigated. ß(3)-knockout mice were able to survive both acute and prolonged cold exposure due to activation of ß(1)-adrenergic receptors. Thus, in the absence of ß(3)-adrenergic receptors, ß(1)-adrenergic receptors are effectively able to signal via cAMP to elicit cAMP-mediated responses and to recruit and activate brown adipose tissue. In addition, we found that in human multipotent adipose-derived stem cells differentiated into functional brown adipocytes, activation of either ß(1)-adrenergic receptors or ß(3)-adrenergic receptors was able to increase UCP1 mRNA and protein levels. Thus, in humans, ß(1)-adrenergic receptors could play an important role in regulating nonshivering thermogenesis.
Description Country affiliation: Sweden
Author Affiliation: Mattsson CL ( Department of Physiology, The Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden.)
ISSN 01931849
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-12-01
Publisher Place United States
e-ISSN 15221555
Journal AJP: Endocrinology and Metabolism
Volume Number 301
Issue Number 6


Source: WHO-Global Index Medicus