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Author Kelsey, Chris R. ♦ Das, Shiva ♦ Gu, Lin ♦ Dunphy, Frank R. ♦ Ready, Neal E. ♦ Marks, Lawrence B.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ CHEMOTHERAPY ♦ ESOPHAGUS ♦ GY RANGE 01-10 ♦ GY RANGE 10-100 ♦ LUNGS ♦ NEOPLASMS ♦ PATIENTS ♦ RADIATION DOSES ♦ RADIOTHERAPY ♦ TOXICITY
Abstract Purpose: To determine the maximum tolerated dose of radiation therapy (RT) given in an accelerated fashion with concurrent chemotherapy using intensity modulated RT. Methods and Materials: Patients with locally advanced lung cancer (non-small cell and small cell) with good performance status and minimal weight loss received concurrent cisplatin and etoposide with RT. Intensity modulated RT with daily image guidance was used to facilitate esophageal avoidance and delivered using 6 fractions per week (twice daily on Fridays with a 6-hour interval). The dose was escalated from 58 Gy to a planned maximum dose of 74 Gy in 4 Gy increments in a standard 3 + 3 trial design. Dose-limiting toxicity (DLT) was defined as acute grade 3-5 nonhematologic toxicity attributed to RT. Results: A total of 24 patients were enrolled, filling all dose cohorts, all completing RT and chemotherapy as prescribed. Dose-limiting toxicity occurred in 1 patient at 58 Gy (grade 3 esophagitis) and 1 patient at 70 Gy (grade 3 esophageal fistula). Both patients with DLTs had large tumors (12 cm and 10 cm, respectively) adjacent to the esophagus. Three additional patients were enrolled at both dose cohorts without further DLT. In the final 74-Gy cohort, no DLTs were observed (0 of 6). Conclusions: Dose escalation and acceleration to 74 Gy with intensity modulated RT and concurrent chemotherapy was tolerable, with a low rate of grade ≥3 acute esophageal reactions.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-12-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 93
Issue Number 5


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