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Author Suzuki, Masao ♦ Ono, Tomoko ♦ Takitani, Shoji
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Subject Keyword ethambutol ♦ high-performance liquid chromatography ♦ plasma ♦ fluorescence detection
Abstract A high-performance liquid chromatographic method for determining ethambutol (EMB) in plasma has been developed. The method involves the clean-up of plasma EMB with an Extrelut-1 column followed by the pre-column fluorescence derivatization of the drug with 9-fluorenylmethylchloroformate. EMB can be determined in the range of 0.18-18nmol/ml, with a relative standard deviation of 1.88-3.39%. The method is applicable to the measurement of EMB concentration in rabbit plasma after single injection of EMB.
ISSN 09106340
Learning Resource Type Article
Publisher Date 1991-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci1985)
Volume Number 7
Issue Number Supple
Page Count 2
Starting Page 949
Ending Page 950


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