|Author||Milanovich, N. ♦ Suh, M. ♦ Jankowiak, R. ♦ Small, G. J. ♦ Hayes, J. M.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||CHEMISTRY ♦ THIAZOLES ♦ FLUORESCENCE ♦ EMISSION SPECTRA ♦ DYES ♦ ORGANIC SULFUR COMPOUNDS ♦ CHEMICAL BONDS ♦ DNA ♦ MOLECULAR STRUCTURE ♦ MOLECULES ♦ HOLES ♦ ELECTRONIC STRUCTURE|
|Abstract||The thiazole orange derivative, TO-PRO-3, and its dimeric analogue, TOTO-3, bind strongly to both double- and single-stranded DNA. Both the bound and the free dye undergo efficient nonphotochemical hole burning. From the structure of the hole burned and the fluorescence line-narrowed spectra, it is concluded that there are multiple modes of binding of the dyes to DNA. In one mode, the absorption, fluorescence, and hole-burned vibronic band structure are similar to those of the free dye. It is proposed that the molecules in this mode are externally bound to the DNA chain. Molecules in the other binding mode are characterized by a strong interaction with DNA. These are proposed to be molecules in intercalated or base-stacked configurations. 27 refs., 7 figs., 2 tabs.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Journal||Journal of Physical Chemistry|
Ministry of Human Resource Development (MHRD) under its National Mission on Education through Information and Communication Technology (NMEICT) has initiated the National Digital Library of India (NDLI) project to develop a framework of virtual repository of learning resources with a single-window search facility. Filtered and federated searching is employed to facilitate focused searching so that learners can find out the right resource with least effort and in minimum time. NDLI is designed to hold content of any language and provides interface support for leading vernacular languages, (currently Hindi, Bengali and several other languages are available). It is designed to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is being developed to help students to prepare for entrance and competitive examinations, to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is being developed at Indian Institute of Technology Kharagpur.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Human Resource Development (MHRD), through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
For any issue or feedback, please write to firstname.lastname@example.org