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Author Sansom, B. F.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE ♦ ANIMALS ♦ BLOOD PLASMA ♦ CALCIUM 45 ♦ CALCIUM PHOSPHATES ♦ COWS ♦ DIFFUSION ♦ GOATS ♦ LABELLED COMPOUNDS ♦ PERFORMANCE ♦ PHOSPHORUS 32 ♦ QUANTITY RATIO ♦ RADIOACTIVITY ♦ SKIN ♦ SOLUBILITY ♦ STRONTIUM 89 ♦ STRONTIUM SULFATES ♦ SUSPENSIONS ♦ TESTING ♦ TRACER TECHNIQUES
Abstract A simple method for establishing a constant concentration of a radioactive tracer in the blood plasma for periods of several days or weeks is described. The method consists of the subcutaneous injection of a saline suspension of a sparingly soluble compound labeled with an isotope of the element concerned. This acts as a depot of radioactivity from which slow leaching occurs into the blood stream. In the case of Ca, calcium orthophosphate labeled with / sup 45/Ca was used as the depot, and for phosphorus the same compound labeled with /sup 32/P. Some experiments with Sr were also carried out using strontium sulfate labeled with /sup 45/Sr as the depot, and the princip1e may presumably be extended to other elements of biological interest. (P.C.H.)
Educational Use Research
Learning Resource Type Article
Publisher Date 1964-04-11
Publisher Department Argicultural Research Council Inst. for Research on Animal Diseases, Compton, Berks, Eng.
Journal Nature
Volume Number 202
Organization Argicultural Research Council Inst. for Research on Animal Diseases, Compton, Berks, Eng.


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