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Author Zeng, Hai Feng ♦ Yan, Shen ♦ Wu, Su Fan
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ANIMAL CELLS ♦ ANIMAL TISSUES ♦ BIOLOGICAL MARKERS ♦ CELL PROLIFERATION ♦ MELANOMAS ♦ PLANT TISSUES
Abstract Malignant melanoma is one of the most common malignancies of the skin cancer and increasing evidences revealed that microRNAs (miRNAs) exert significant effects in melanoma. In the present study, the underlying function of microRNA-153-3p (miR-153-3p) in melanoma was investigated from different levels, including cell level, protein level and gene level. Our results showed that expression of miR-153-3p was lower in melanoma tissues and melanoma cells compared with the para-tumor tissue and normal melanocytes. The overexpression of miR-153-3p inhibited the cell proliferation and invasion, at the same time promoted cell apoptosis. Moreover, we identified that snail family transcriptional repressor 1 (SNAI1) is the direct target of miR-153-3p, and there is a negative correlation between miR-153-3p level and SNAI1 expression. In summary, we presented the evidences that miR-153-3p may act as a tumor suppressor by down-regulating the expression of SNAI1 in melanoma and miR-153-3p might be a potential biomarker in the diagnosis and treatment of malignant melanoma. - Highlights: • Revealed the expression of miR-153-3p was notably down-regulated in melanoma tissues and cell line. • Confirmed that miR-153-3p modulate cell proliferation and invasion by suppressing the expression of SNAI1. • Mir-153-3p may use as a biomarker for diagnosis and treatment of malignant melanoma.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-05-20
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 487
Issue Number 1


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