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Author Silva, Suresh de ♦ Mackie, Simon ♦ Aslan, Peter ♦ Cade, David ♦ Delprado, Warick
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ANIMAL TISSUES ♦ ATROPHY ♦ COMPARATIVE EVALUATIONS ♦ FIBROSIS ♦ FLUOROSCOPY ♦ KIDNEYS ♦ MICROSPHERES ♦ NECROSIS ♦ NEOPLASMS ♦ PLANT TISSUES ♦ RADIATION DOSES ♦ RADIOEMBOLIZATION ♦ RECOMMENDATIONS ♦ RESINS ♦ SWINE ♦ VASCULAR DISEASES ♦ YTTRIUM ♦ YTTRIUM 90
Abstract BackgroundIntra-arterial brachytherapy with yttrium-90 ({sup 90}Y) resin microspheres (radioembolization) is a procedure to selectively deliver high-dose radiation to tumors. The purpose of this research was to compare the radioembolic effect of {sup 90}Y-radioembolization versus the embolic effect of bland microspheres in the porcine kidney model.MethodsIn each of six pigs, ~25–33 % of the kidney volume was embolized with {sup 90}Y resin microspheres and an equivalent number of bland microspheres in the contralateral kidney. Kidney volume was estimated visually from contrast-enhanced fluoroscopy imaging. Morphologic and histologic analysis was performed 8–9 weeks after the procedure to assess the locations of the microspheres and extent of tissue necrosis from {sup 90}Y-radioembolization and bland embolization. A semi-quantified evaluation of the non-acute peri-particle and perivascular tissue reaction was conducted. All guidelines for the care and use of animals were followed.ResultsKidneys embolized with {sup 90}Y-radioembolization decreased in mass by 30–70 % versus the contralateral kidney embolized with bland microspheres. These kidneys showed significant necrosis/fibrosis, avascularization, and glomerular atrophy in the immediate vicinity of the {sup 90}Y resin microspheres. By contrast, glomerular changes were not observed, even with clusters of bland microspheres in afferent arterioles. Evidence of a foreign body reaction was recorded in some kidneys with bland microspheres, and subcapsular scarring/infarction only with the highest load (4.96 × 10{sup 6}) of bland microspheres.ConclusionThis study showed that radioembolization with {sup 90}Y resin microspheres produces localized necrosis/fibrosis and loss of kidney mass in a porcine kidney model. This result supports the study of {sup 90}Y resin microspheres for the localized treatment of kidney tumors.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-12-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 39
Issue Number 12


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