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Author Balhorn, R.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE, BASIC STUDIES ♦ DNA ♦ MOLECULAR STRUCTURE ♦ VIRUSES
Abstract Toroidal DNA condensates have received considerable attention for their possible relationship to the packaging of DNA in viruses and in general as a model of ordered DNA condensation. A spool-like model has primarily been supported for DNA organization within toroids. However, our observations suggest that the actual organization may be considerably different. We present an alternate model in which DNA for a given toroid is organized within a series of equally sized contiguous loops that process about the toroid axis. A related model for the toroid formation process is also presented. This kinetic model predicts a distribution of toroid sizes for DNA condensed from solution that is in good agreement with experimental data. 25 refs., 5 figs.
ISSN 00278424
Educational Use Research
Learning Resource Type Article
Publisher Date 1995-04-11
Publisher Place United States
Volume Number 92
Issue Number 8


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