Thumbnail
Access Restriction
Open

Author Westmeier, Dana ♦ Stauber, Roland H. ♦ Docter, Dominic
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ BIOTECHNOLOGY ♦ CHEMICAL PROPERTIES ♦ MOLECULES ♦ NANOMATERIALS ♦ NANOPARTICLES ♦ PROTEINS ♦ REVIEWS ♦ TOXICITY
Abstract Besides the wide use of engineered nanomaterials (ENM) in technical products, their application spectrum in biotechnology and biomedicine is steadily increasing. In complex physiological environments the physico-chemical properties and the behavior of nanoparticles (NPs) are challenging to characterize. Biomolecules rapidly adsorb to the nanomaterial, leading to the formation of the protein/biomolecule corona, which critically affects the nanomaterials' (patho)biological and technical identities. This formation can trigger an immune response and affect nanoparticles' toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the (protein)corona-nanoparticle interaction and discuss how the corona modulates both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers. - Highlights: • “Nanotoxicology” has emerged an autonomous field with an explosive growth. • Nanomaterials adsorb (bio)molecules forming the so-called (bio)molecule corona. • (Fine-)tune of the corona composition could enable new possibilities in nanomedicine.
ISSN 0041008X
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-05-15
Publisher Place United States
Journal Toxicology and Applied Pharmacology
Volume Number 299


Open content in new tab

   Open content in new tab