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Author Pollom, Erqi L. ♦ Deng, Lei ♦ Pai, Reetesh K. ♦ Brown, J. Martin ♦ Giaccia, Amato ♦ Loo, Billy W. ♦ Shultz, David B. ♦ Le, Quynh Thu ♦ Koong, Albert C. ♦ Chang, Daniel T.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ANGIOGENESIS ♦ NEOPLASMS ♦ PATIENTS ♦ PHENOBARBITAL ♦ RADIOTHERAPY ♦ REVIEWS ♦ TOXICITY
Abstract Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-07-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 92
Issue Number 3


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