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Author Movafegh, Ali ♦ Mohammadi, Sussan Soltani ♦ Jabbarzadeh, Siavosh
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Wolters Kluwer Medknow Publications
File Format HTM / HTML
Date Created 2017-03-02
Copyright Year ©2015
Language English
Subject Domain (in LCC) RD78.3-87.3 ♦ RG1-991
Subject Keyword Anesthesiology ♦ Shivering ♦ Gynecology and obstetrics ♦ Granisetron ♦ Medicine ♦ Spinal anesthesia ♦ Thermoregulation ♦ Surgery ♦ Nausea and vomiting
Abstract Background: Hypothermia, shivering, nausea and vomiting are frequent perioperative events in patients undergoing cesarean delivery under spinal anesthesia. Apart from physical warming for shivering many drugs have also been used for prevention of these events. Objectives: We conducted a randomized double-blinded clinical trial to evaluate the effect of a single drug, granisetron on prevention of shivering, nausea and vomiting during cesarean section performed under spinal anesthesia. Materials and Methods: One hundred American Society of Anesthesiologists I-II patients undergoing elective cesarean section under spinal anesthesia were randomly allocated into two groups, control saline (n = 50) or granisetron groups (n = 50). Warmed (37°C) lactated ringer′s solution was infused over 15 min before anesthesia. Spinal block was performed with the same technique in both groups. In the saline group 3 ml of 0.9% saline and in granisetron 3 mg (3 ml) granisetron was injected intravenously after intrathecal injection at identical times. Shivering, maximum and minimum level of spinal block, core body temperature, nausea and vomiting and need to treat shivering with intravenous pethidine and neonates APGAR scores were all recorded. Results: Demographic data, median of sensory block level and mean core body temperature were not statistically different in groups. Eight percent (4/50) of patients in granisetron and 54% (27/50) of patients in the saline group had shivering during the perioperative period that was treated with pethidine (P = 0.001). Ten patients (20%) in granisetron and 30 patients (60%) in saline group had nausea (P = 0.002). No patients in both groups needed rescue medication. 1 st and 5 th minutes APGAR scores of neonates were not statistically different in the groups. Ten patients (20%) in granisetron and 30 patients (60%) in saline group had nausea (P = 0.002). Conclusions: Granisetron is an effective way to prevent shivering, nausea and vomiting during cesarean delivery under spinal anesthesia with no effect on APGAR score.
ISSN 22494472
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2015-01-01
e-ISSN 22494472
Journal Journal of Obstetric Anaesthesia and Critical Care
Volume Number 5
Issue Number 1
Page Count 5
Starting Page 22
Ending Page 26


Source: Directory of Open Access Journals (DOAJ)