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Author Rathore, Vikram Singh ♦ Das, Kapildev ♦ Kundu, Sourav ♦ Datta, Pijush Kanti ♦ Gharami, Ramesh Chandra ♦ Das, Nilay Kanti ♦ Choudhury, Sourav
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher PAGEPress Publications
File Format HTM / HTML
Date Created 2010-01-22
Copyright Year ©2010
Language English
Subject Domain (in LCC) RL1-803
Subject Keyword Dermatology ♦ Local excision ♦ Medicine ♦ Retinoid ♦ Keratoacanthoma centrifugum marginatum
Abstract We describe a case of a 65-year-old male presenting with a large plaque with a rolled-out interrupted margin, atrophic center, and island of normal skin over the left arm. It grew peripherally with central healing, and there was a history of recurrence after inadequate excision. Investigations ruled out other clin­ical mimickers; namely, squamous cell carcinoma, lupus vulgaris, botryomycosis, and blastomycosis-like pyoderma. Histopathological sections showed irregularly shaped craters filled with keratin and epithelial pearl but no evidence of granuloma or cellular atypia. Clinico­pathological correlation proved the lesion to be keratoacanthoma centrifugum marginatum (KCM), a rare variant of keratoacanthoma, which spreads centrifugally, attains a huge size, and never involutes spontaneously. Treatment of KCM has been a problem always and, in our case, systemic retinoid (acitretin for three months) proved ineffective. The patient also had a history of recurrence following surgical intervention previously, necessitating wide excision to achieve complete clearance of tumor cells. Hence, after failure of retinoid therapy, the decision of excision with a 1-centimeter margin was taken and the large defect was closed by a split thickness skin graft. The graft uptake was satisfactory, and the patient is being followed-up presently and shows no signs of recurrence after six months, highlighting wide local excision as a useful treatment option.
ISSN 20367392
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Book
Publisher Date 2010-01-01
e-ISSN 20367392
Journal Dermatology Reports
Volume Number 2
Issue Number 1
Starting Page e1
Ending Page e1


Source: Directory of Open Access Journals (DOAJ)