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Author Lacasana, Marina ♦ Publica, CIBER de Epidemiologia y. Salud ♦ Lopez-Flores, Inmaculada ♦ Rodriguez-Barranco, Miguel ♦ Aguilar-Garduno, Clemente ♦ Blanco-Munoz, Julia ♦ Perez-Mendez, Oscar ♦ Gamboa, Ricardo ♦ Gonzalez-Alzaga, Beatriz ♦ Bassol, Susana ♦ Cebrian, Mariano E.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ENZYMES ♦ GENOTYPE ♦ PESTICIDES ♦ THYROID ♦ THYROID HORMONES ♦ TOXICITY ♦ TSH ♦ BODY ♦ ENDOCRINE GLANDS ♦ GLANDS ♦ HORMONES ♦ ORGANIC COMPOUNDS ♦ ORGANS ♦ PEPTIDE HORMONES ♦ PITUITARY HORMONES ♦ PROTEINS
Abstract Organophosphate pesticides are widely used in agricultural purposes. Recently, a few studies have demonstrated the ability of these chemicals to alter the function of the thyroid gland in human. Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. This study evaluates the interaction between exposure to organophosphate compounds and PON1 enzyme activity on serum levels of TSH and thyroid hormones in a population of workers occupationally exposed to pesticides. A longitudinal study was conducted on a population of floriculture workers from Mexico, during two periods of high and low-intensity levels of pesticide application. A structured questionnaire was completed by workers containing questions on sociodemographic characteristics and other variables of interest. Urine and blood samples were taken, and biomarkers of exposure (dialkylphosphates), susceptibility (PON1 polymorphisms and activity) and effect (thyroid hormone levels) were determined. Interaction between dialkylphosphates and PON1 polymorphisms or PON1 activity on hormone levels was evaluated by generalized estimating equation (GEE) models. A significant interaction was found between serum diazoxonase activity and total dialkylphosphates ({Sigma}DAP) on TSH levels. Thus, when PON1 activity was increased we observed a decrease in the percentage of variation of TSH level for each increment in one logarithmic unit of the {Sigma}DAP levels. This interaction was also observed with the PON1{sub 192}RR genotype. These results suggest a stronger association between organophosphate pesticides and thyroid function in individuals with lower PON1 activity.
ISSN 0041008X
Educational Use Research
Learning Resource Type Article
Publisher Date 2010-11-15
Publisher Place United States
Journal Toxicology and Applied Pharmacology
Volume Number 249
Issue Number 1


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