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Author Esegal, Menahem
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Frontiers Media S.A.
File Format HTM / HTML
Date Created 2014-09-16
Copyright Year ©2014
Language English
Subject Domain (in LCC) RC321-571 ♦ QM1-695
Subject Keyword Neuropsychiatry ♦ Biological psychiatry ♦ Neurosciences ♦ Human anatomy ♦ STIM ♦ IP3 receptors ♦ Science ♦ Internal medicine ♦ Medicine ♦ Ryanodine receptors ♦ Dendritic Spines ♦ Orai
Abstract Despite decades of research, the role of calcium stores in dendritic spines structure, function and plasticity is still debated. The reasons for this may have to do with the multitude of overlapping calcium handling machineries in the neuron, including stores, voltage and ligand gated channels, pumps and transporters. Also, different cells in the brain are endowed with calcium stores that are activated by different receptor types, and their differential compartmentalization in dendrites, spines and presynaptic terminals complicates their analysis. In the present review we address several key issues, including the role of calcium stores in synaptic plasticity, their role during development, in stress and in neurodegenerative diseases. Apparently, there is increasing evidence for a crucial role of calcium stores, especially of the ryanodine species, in synaptic plasticity and neuronal survival.
ISSN 16625129
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2014-07-01
e-ISSN 16625129
Journal Frontiers in Neuroanatomy
Volume Number 8


Source: Directory of Open Access Journals (DOAJ)