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Author Liu, Chao ♦ Huang, Jian ♦ Shen, Cailiang ♦ Huang, Dake ♦ Zhang, Dijuan ♦ Xie, Fenfen ♦ Qi, Weiqin ♦ Sun, Ruyu ♦ Shen, Yuxian ♦ Wang, Shenghua
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Frontiers Media S.A.
File Format HTM / HTML
Date Created 2017-11-06
Copyright Year ©2017
Language English
Subject Domain (in LCC) RC321-571 ♦ QM1-695
Subject Keyword Biological psychiatry ♦ Ependymal cells ♦ Subventricular zone ♦ Neurosciences ♦ Human anatomy ♦ Internal medicine ♦ Subgranular zone ♦ Adult neural stem cell ♦ Medicine ♦ Neuropsychiatry ♦ Science ♦ PAX6 ♦ BAF45D
Abstract Adult neurogenesis is important for the development of regenerative therapies for human diseases of the central nervous system (CNS) through the recruitment of adult neural stem cells (NSCs). NSCs are characterized by the capacity to generate neurons, astrocytes, and oligodendrocytes. To identify key factors involved in manipulating the adult NSC neurogenic fate thus has crucial implications for the clinical application. Here, we report that BAF45D is expressed in the subgranular zone (SGZ) of the dentate gyrus, the subventricular zone (SVZ) of the lateral ventricle, and the central canal (CC) of the adult spinal cord. Coexpression of BAF45D with glial fibrillary acidic protein (GFAP), a radial glial like cell marker protein, was identified in the SGZ, the SVZ and the adult spinal cord CC. Quantitative analysis data indicate that BAF45D is preferentially expressed in the neurogenic zone of the LV and the neurons of the adult CNS. Furthermore, during the neuroectoderm differentiation of H9 cells, BAF45D is required for the expression of PAX6, a neuroectoderm determinant that is also known to regulate the self-renewal and neuronal fate specification of adult neural stem/progenitor cells. Together, our results may shed new light on the expression of BAF45D in the adult neurogenic zones and the contribution of BAF45D to early neural development.
ISSN 16625129
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2017-11-01
e-ISSN 16625129
Journal Frontiers in Neuroanatomy
Volume Number 11


Source: Directory of Open Access Journals (DOAJ)